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Anatomy
The Sciatic nerve is the longest and largest nerve in the body and is commonly affected by certain conditions. The nerve
exits through the lower spinal column and runs behind the hip joint, exits on the posterior side of the lower extremity (back
of thigh) and continues to extend down to the foot. The Sciatic nerve innervates and controls many of the muscle groups
in the lower extremity and provides sensation to the thigh, leg and foot. The condition "sciatica" refers to pain that
radiates along the path of this nerve.
Pathology
The sciatic nerve can be affected by many different conditions and disease states. Many of these conditions ultimately
lead the nerve to become pinched or stretched. Some of the most commonly seen conditions that produce sciatica are:
• Herniated or Bulging Disc – is the most common cause of sciatica. Separating each vertebra (spine bones) are
discs that act as cushions to minimize the impact that the spinal column receives. Since the discs are designed to be soft
and provide support, they have a tendency to herniate backwards through the outer disc segment and nearby ligaments.
This disc can irritate an adjacent nerve by physical contact or by leaking caustic substances directly onto the nerve. Disk
disease is one of the most common causes of chronic lower back pain and accounts for approximately 10% of all low back
pain complaints.
• Spinal Stenosis – is a disorder due to narrowing of the spinal canal causing nerve or spinal cord impingement. The
condition often results in persistent pain in the lower back and lower extremities. Difficulty walking, decreased sensation in
the lower extremities, and decreased physical activity may also be seen. Many people with spinal stenosis present with
bilateral (both sides) sciatica.
• Piriformis syndrome – The piriformis is a large muscle that is part of the pelvis. When this muscle becomes
inflamed or overused this muscle can trap the sciatic nerve deep in the buttock causing sciatica.
• Facet Hypertrophy – The facet joints allow for movement especially backwards extension. When the facet joints
become arthritic they can become knobby and large. They also can develop cysts. The larger joints can irritate exiting
nerve roots causing sciatica.
• Less commonly, sciatica can be due to tumor, pelvic infections, and other causes.
Diagnosis
Diagnosis of sciatica is most often done clinically by a medical physician. The physician performs a physical examination
demonstrating tenderness over certain areas of the spine as well as assessing the various limitations in movement of the
lower extremity.
The physician may also order radiological imaging such as x-ray, CT scan, MRI, or bone scan depending on his clinical
suspicion. Currently MRIs are that standard of care to visualize chronic back pain and are especially useful before any
procedures are undertaken. If a history of cancer, IV drug use, HIV infection, or recent steroid use is known then the
physician will most likely order additional studies.
Treatment
• Pharmacotherapy - NSAID’s (Ibuprofen like drugs), Acetaminophen, membrane stabilizing drugs, muscle relaxants,
and other analgesics are often used in the management of pain associated with sciatica.
• Epidural Steroid Injections (ESI) - The procedure involves injecting a medication into the epidural space, where the
actual irritated nerve root is located. This injection includes both a long-lasting steroid and a local anesthetic (lidocaine,
bupivacaine). The steroid reduces the inflammation and irritation and the anesthetic works to interrupt the pain-spasm
cycle and nociceptor (pain signal) transmission (Boswell 2007). The combination medicine then spreads to other levels
and portions of the spine, reducing inflammation and irritation. The entire procedure usually takes less than fifteen
minutes.
The most important and greatest success achieved with the use of epidural steroid injections (ESI) is the rapid relief of
symptoms that allows patients to experience enough relief to become active again. With this they regain the ability to
resume their normal daily activities.
A large study in 2005 including two hundred and twenty-eight patients with a clinical diagnosis of unilateral sciatica were
randomized to either three lumbar ESIs of or a placebo injection at intervals of three weeks. The ESI group demonstrated
a 75% pain improvement over the placebo group (Arden 2005).
• Lysis of Adhesions - Also know as the “Racz Procedure“ this procedure has proven effective in removing excessive
scar tissue in the epidural space when conservative treatment has failed. A study performed in 2005 said “a spinal
adhesiolysis with targeted delivery of local anesthetic and steroid is an effective treatment in a significant number of
patients with chronic low back and lower extremity pain without major adverse effects.”
• Infusions Techniques- The procedure involves inserting a small catheter through a needle into the epidural space
or directly next to affected nerves. Local anesthetic and other medicines are often given through the catheter for
extended time periods. When the nerves are blocked continuously with an infusion, pain relief can be dramatic and long
lasting.
• Transcutaneous Electrical Stimulation (TENs) - this pain relief technique is a passive process with no known side
effects. TENS decreases the perception of pain and may be used to control acute and chronic pain. There are several
patches placed on your skin in the area that is affected and mild electrical current generates stimuli. This stimuli confuses
the spinal cord and brain pain processing centers. Painful signals are replaced by tingling electrical signals. This
provides relaxation of the muscle, improves mobility, and can relieve pain.
• Spinal Cord Stimulation (SCS) - an implanted electrical device that decreases the perception of pain by confusing
the spinal cord and brain pain processing centers. Initially a trial is done to see if this device will help you long-term. In
the initial trial, your pain physician places a small electrical lead through a needle in the epidural space. Painful signals
are replaced by tingling electrical signals. If you have success in your trial, you may decide to have a permanent SCS
device implanted.
• Deep Tissue Massage - focal rubbing of the tender areas may help relieve muscle spasms or contractions and
improve the discomfort associated with it. Massage can also help you relax, decreasing stress and tension.
• Acupuncture – Small needles are inserted into the skin. These needle cause your body to release hormones called
“endorphins“, which are your body’s natural pain reliever. Acupuncture can also help you relax, decreasing stress,
tension, and muscular spasm.
• Physical therapy - Physical Therapy helps improve symptoms of sciatica by increasing flexibility, range of motion,
posture, and improving muscle strength.
• Nutrition and Exercise - Exercise improves the pain of sciatica by increasing flexibility and range of motion. Another
benefit is the releases hormones called “endorphins,“ which are your body’s natural pain reliever. Nutrition and healthy
eating may be powerful treatments to combat nutritional deficits.
• Intrathecal Pump Implants - Implanted pain pumps are also available which can be extremely helpful providing long-
term pain control. The effectiveness of intrathecal therapy in patients suffering from nociceptive pain showed a pain
reduction in 66.7% of patients experiencing pain due to cancer (Becker 2000).
• Disc Decompression – a needle is inserted through the skin into the affected disc. Disc material is suctioned out of
the bulging disc and pressure is relieved within the disc.
• Trigger Point Injections (TPIs) – can be an effective treatment for muscle spasms. The procedure involves injecting
a local anesthetic and steroid into a “Trigger Point.” Perfoming a Piriformis Injection can be considered a type of TPI.
• Botox – used in treating neck pain is an exciting new treatment that is widely accepted among modern medicine. In
2005 “Botulinum toxin Type A (BtA) became the first line therapy for the treatment for cervical dystonia.” Although a
single injection of BtA is effective, multiple injection cycles seem to work better for patients (Costa 2005). Botox injections
have also been found to be effective in patients with whiplash injuries. Along with reductions in pain patients were found
to have improved range of motion ((Juan 2004).
• Biofeedback - is a treatment that teaches a patient to become aware of processes that are normally thought to be
involuntary inside of the body (such as blood pressure, temperature and heart rate control). This method enables you to
gain some conscious control of these processes, which can influence and improve your level of pain. A better awareness
of ones body teaches one to effectively relax and this can help to relieve pain.
Articles
Rheumatology (Oxford). 2005 Nov;44(11):1399-406. Epub 2005 Jul 19 Arden NK, Price C, Reading I, Stubbing J,
Hazelgrove J, Dunne C, Michel M, Rogers P, Cooper C; WEST Study Group. Rheumatology (Oxford). 2005 Nov;44(11):
1399-406. Epub 2005 Jul 19 PMID: 16030082
Interventional Techniques: Evidence-based Practice Guidelines in the Management of Chronic Spinal Pain. Boswell et.
All. Pain Physician 2007; 10:7-111
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Sciatica
by Nicole Berardoni M.D, Tory McJunkin M.D, and Paul Lynch M.D
Sciatica is also called lower extremity (L5/S1) radiculitis or
radiculopathy and is a condition characterized by weakness or
sensory changes along the sciatic nerve pathway. The sensory
changes are often described as “pins and needles” and can extend
down the buttock, leg and foot. Symptoms of serious concern
include severe nerve impingement, bladder incontinence, bowel
incontinence, lower extremity weakness, and profound loss of
sensation. Loss of bowel or bladder function with sensory deficits
and weakness is termed “Cauda Equina Syndrome” and is a true
medical emergency.
by Nicole Berardoni M.D, Tory McJunkin M.D, and Paul Lynch M.D
Sciatica is also called lower extremity (L5/S1) radiculitis or
radiculopathy and is a condition characterized by weakness or
sensory changes along the sciatic nerve pathway. The sensory
changes are often described as “pins and needles” and can extend
down the buttock, leg and foot. Symptoms of serious concern
include severe nerve impingement, bladder incontinence, bowel
incontinence, lower extremity weakness, and profound loss of
sensation. Loss of bowel or bladder function with sensory deficits
and weakness is termed “Cauda Equina Syndrome” and is a true
medical emergency.
Book I - Pain Syndromes
Chapter 1 Low Back Pain
Chapter 2 Neck Pain
Chapter 3 Cancer Pain
Chapter 4 Headaches
Chapter 5 Spinal Stenosis
Chapter 6 Sciatica
Chapter 7 Arthritis
Chapter 8 Fibromyalgia
Chapter 9 Motor Vehicle Injuries
Chapter 10 Complex Regional Pain
Syndrome
Chapter 11 Vertebral Body
Fractures
Chapter 12 Hip and Leg Pain
Chapter 13 Diabetic Peripheral
Neuropathy
Book II - Interventional Procedures
Chapter 14 Epidural Steroid
Injection
Chapter 15 Facet Injections/Medial
Branch Blocks
Chapter 16 Radiofrequency Ablation
Chapter 17 Spinal Cord Stimulator
Implants
Chapter 18 IntraDiscal
Electrothermal Therapy (IDET)
Chapter 19
Vertebroplasty/Kyphoplasty
Chapter 20 Discography
Chapter 21 Percutaneous
Discectomy
Chapter 22 Occipital Nerve Block
Chapter 23 Sympathetic Block
Chapter 24 Stellate Ganglion Block
Chapter 25 Intrathecal Pump
Implants
Chapter 26 Caudal Steroid Injection
Chapter 27 Adhesiolysis
Chapter 28 Cervical Steroid
Injection
Chapter 29 Sacroiliac Joint
Injections
Chapter 30 Celiac Plexus Block
Chapter 31 Head and Neck
Procedures
Chapter 32 Joint Injections
Chapter 33 Continuous Catheter
Nerve Blocks
Chapter 34 Peripheral Nerve
Stimulation/Field Stimulation
Chapter 35 Disc Denervation
Book III Other Treatments
Chapter 36 Medication Management
Chapter 37 Acupuncture
Chapter 38 Prolotherapy
Chapter 39 Botox
Chapter 40 Massage
Chapter 41 Alternative and
Complementary Medicines
Chapter 42 Exercise and Nutrition
Counseling
Chapter 43 Prayer
Chapter 44 Cognitive Behavioral
Therapy
Chapter 45 Group Therapy
Chapter 46 Biofeedback
Chapter 47 Chiropractic
Manipulations
Chapter 48 Vitamin Supplements
Chapter 49 Customized
Pharmaceutical Formulations
Chapter 50 Hormone Therapy
Frequently Asked Questions
Chapter 1 Low Back Pain
Chapter 2 Neck Pain
Chapter 3 Cancer Pain
Chapter 4 Headaches
Chapter 5 Spinal Stenosis
Chapter 6 Sciatica
Chapter 7 Arthritis
Chapter 8 Fibromyalgia
Chapter 9 Motor Vehicle Injuries
Chapter 10 Complex Regional Pain
Syndrome
Chapter 11 Vertebral Body
Fractures
Chapter 12 Hip and Leg Pain
Chapter 13 Diabetic Peripheral
Neuropathy
Book II - Interventional Procedures
Chapter 14 Epidural Steroid
Injection
Chapter 15 Facet Injections/Medial
Branch Blocks
Chapter 16 Radiofrequency Ablation
Chapter 17 Spinal Cord Stimulator
Implants
Chapter 18 IntraDiscal
Electrothermal Therapy (IDET)
Chapter 19
Vertebroplasty/Kyphoplasty
Chapter 20 Discography
Chapter 21 Percutaneous
Discectomy
Chapter 22 Occipital Nerve Block
Chapter 23 Sympathetic Block
Chapter 24 Stellate Ganglion Block
Chapter 25 Intrathecal Pump
Implants
Chapter 26 Caudal Steroid Injection
Chapter 27 Adhesiolysis
Chapter 28 Cervical Steroid
Injection
Chapter 29 Sacroiliac Joint
Injections
Chapter 30 Celiac Plexus Block
Chapter 31 Head and Neck
Procedures
Chapter 32 Joint Injections
Chapter 33 Continuous Catheter
Nerve Blocks
Chapter 34 Peripheral Nerve
Stimulation/Field Stimulation
Chapter 35 Disc Denervation
Book III Other Treatments
Chapter 36 Medication Management
Chapter 37 Acupuncture
Chapter 38 Prolotherapy
Chapter 39 Botox
Chapter 40 Massage
Chapter 41 Alternative and
Complementary Medicines
Chapter 42 Exercise and Nutrition
Counseling
Chapter 43 Prayer
Chapter 44 Cognitive Behavioral
Therapy
Chapter 45 Group Therapy
Chapter 46 Biofeedback
Chapter 47 Chiropractic
Manipulations
Chapter 48 Vitamin Supplements
Chapter 49 Customized
Pharmaceutical Formulations
Chapter 50 Hormone Therapy
Frequently Asked Questions